The Gut-Brain Axis Could Accelerate Autism Understanding

The gut microbiota is believed to play an important role in the development of certain disorders, including autism. We know that many children with autism have digestive problems and microbial imbalances in their guts. The exact connection between autism and the gut microbiome, however, is not yet clear.

To study this emerging issue, our team at the Simons Foundation analyzed 25 datasets collected across 18 studies that involved 600 children with autism. We created and ran an algorithm to identify differences between kids with autism and their neurotypical counterparts. We then correlated the microbiome against so-called cytokines, which are immune markers, to see how the gut microbiome is linked to individuals’ immunity and inflammation. ¹

This is important because many chronic disorders, such as inflammatory bowel disease and diabetes, demonstrate components of immune dysfunction. Identifying the immune-microbe link in autism not only creates new opportunities for managing autism symptoms, but it also introduces ideas regarding how the microbiome could be manipulated to regulate immune response.

Gut Microbiota May Signal Autism

When we looked at the microbes predicted to be associated with autism and compared them with microbiota likely associated with neurotypical controls, we observed a strong difference between the two groups. Further investigation suggested that we could distinguish accurately between individuals with autism and neurotypical controls just by using their measured gut microbiota. This means that future research might unlock autism diagnoses through gut microbiome analysis, potentially guiding symptom management and therapeutic developments.

[10 Foods (and Supplements and Vitamins!) to Boost Your ADHD Brain]

When we compared the gut-brain axis — the gut microbiota and human brain pathways, or the enzymes responsible for the breakdown of products in the brain — we observed a strong overlap between pathways detected in the gut and those detected in the brain. This suggests that diet affects gut diversity and brain function, from thinking to mood.

GI and Sleep Problems

Many children with autism have gastrointestinal (GI) and sleep problems. In one study, researchers found that the chances for behavioral problems substantially increase when children have GI and sleep problems. ²

Parents should track foods eaten, bowel movements, and sleep patterns to establish connections between these factors and their child’s symptoms. Preventing or treating GI symptoms may provide children with some relief and help them sleep through the night.

Research into the gut-brain axis, and what this correlation can tell us about certain conditions like autism and depression, is still new. In the near future, it is possible that knowledge of gut bacteria will help determine predictive biomarkers of disease, with implications for new therapeutics. What we know about the gut-brain axis will look very different 5 to 10 years from now.

Autism and Gastrointestinal Issues: Next Steps

• Download: Autism Evaluation Checklist
• Read: The ADHD Diet Plan — Healthy Foods and Supplements for Kids & Adults 
• Read: Autism vs. ADHD — A Parent’s Guide to Tricky Diagnoses

Jamie Morton, Ph.D., is an independent consultant who has previously worked for the National Institute of Child Health and Human Development.

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